- 作者: Barton, Derek H.R. ; Ozbalik, Nubar
- 作者服務機構: Chemistry Dept., Texas AM Univ., U.S.A.
- 中文摘要: The advantages of radical reactions for Organic Synthesis are summarised. Based on the idea of the disciplined radical, it is now possible to design radical reactions which afford a good yield of a single desired product. The system needs to contain a disciplinary group. In the case of radical reactions involving tin hydrides, it is the weak tin-hydrogen bond that is the disciplinary group. For the esters of thiohydroxamic acids, the disciplinary group is the thione function. Examples are given. Recent work has involved the design of stereospecific radical reactions. The hindrance around one chiral center is used to control the formation of the second. The ketal of (+)-(2R,3R) tartaric acid gives excellent stereospecificity (c. a. 24:1) with retention of configuration.
- 英文摘要: --
- 中文關鍵字: Radical Reaction; Organic Synthesis; Selectivity; Stereospecificity
- 英文關鍵字: 游離基反應;有機合成;選擇性;立體定向性;立體特異性