- 作者: 李宗徽,莊聲宏,徐鳳麟,吳政億
- 作者服務機構: Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taipei 110, Taiwan, R.O.C.
- 中文摘要: From the methanolic extract of the leaves of Planchonella duclitan, 2a,3a,19a,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid (1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 mM.
- 英文摘要: --
- 中文關鍵字: Planchonella duclitan; Sapotaceae; Leaves; Triterpene acids; 2a,3a,19a,23-tetrahydroxy- 13,27-cyclours-11-en-28-oic acid; HT29; MCF-7.
- 英文關鍵字: --