- 作者: 蕭明仁 ; 謝墣 ; 賴貞秀
- 作者服務機構: Inst. Of Chemistry,Academia Sinica, R.O.C.
- 中文摘要: A new synthesis of amrinone from 5-(4-pyridinyl)-2 (1H)- pyridone (5) is reported. Nitration at C-3 of the pyridone ring of (5) followed by reduction afforded amrinone. Another synthetic route was also carried out by bromination at C-3 of the pyridone ring of (5) followed by substitution with sodium azide to give the corresponding azide compound which was reduced to amrinone.
- 英文摘要: --
- 中文關鍵字: Amrinone; Cardiotonic Agent; 3,4'-Bipyridine; N- Ethoxycarbonylpyridinium Chloride; Hydrogenolysis; Nitration; Bromination; Reduction
- 英文關鍵字: 強心劑;3;4-二啶;N-乙酯基啶鎉氯化物;氫解反應;硝化反應;溴化反應;還原反應