- 作者: Jennifer H Ho and Chuang-Ye Hong
- 作者服務機構: Graduate Institute of Clinical Medicine, Taipei Medical University, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要: Magnolia officinalis has been widely used in traditional Chinese medicine. Magnolol, an active component isolated from Magnolia officinalis, is known to be a cardiovascular protector since 1994. The multiplex mechanisms of magnolol on cardiovascular protection depends on cell types and dosages, and will be reviewed and discussed in this article. Magnolol under low and moderate dosage possesses the ability to protect heart from ischemic/reperfusion injury, reduce atherosclerotic change, protect endothelial cell against apoptosis, inhibit neutrophil-endothelial adhesion. The moderate to high concentration of magnolol mainly acts on smooth muscle cells and platelets. Magnolol induces apoptosis in vascular smooth muscle cells at moderate concentration and inhibits proliferation at moderate and high concentration. High concentration of magnolol also abrogates platelet activation, aggregation and thrombus formation. Magnolol also serves as an smooth muscle relaxant only upon the high concentration. Oral intake of magnolol to reach the therapeutic level for cardiovascular protection is applicable, thus makes magnolol an agent of great potential for preventing cardiovascular diseases in high-risk patients.
- 中文關鍵字: --
- 英文關鍵字: Magnolol, Cardiomyocytes, Vascular endothelial cells, Smooth muscle cells, Inflammation, Antioxidant