• 作者： 朱健次
• 作者服務機構： 國立臺灣大學醫學院細菌學科
• 中文摘要： 本研究在探討?疹病毒第一型（HSV-1）於三種溫度敏感（ts）變種細胞株內繁殖之情形。由
  化學藥物引起變形之老鼠肝臟細胞，不論其為ts變種或原型，於適溫或非適溫，HSV-1之繁
  殖皆很差。以HSV-1感染兩個BSC-1細胞株之ts變種，培養於適溫或非適溫，病毒繁殖之
  情形皆與在原型細胞內一樣良好。BHK-21細胞之一ts變種，在本研究中證實此ts變種細胞
  在非適溫培養時，對HSV-1之繁殖有抑制作用，由此鑑定出此細胞之某基因產物為HSV-1繁
  殖所必需。、
• 英文摘要： Replication of HSV-1 in 3 different is mu-tant cell lines was examined. HSV-1 grewpoorly at both permissive and nonpermissivetemperature in chemically transformed ts ratliver cells and in the wt cells from which theywere derived. In two is mutant BSC-1 celllines, HSV-1 replication was equally efficientboth at the nonpermissive temperature and per-missive temperature. The yields of infectiousvirus produced in mutant cells was the same asthat produced in wt cells. In contrast, SV40replication was blocked in an early stage ofinfection in these cells. These data suggestedthat the regulatory mechanism for SV40 andHSV-1 replication is different in BSC-1 cells.A is defect in BHK-21 cells which inhibitedAd2 replication also inhibited the growth ofHSV-1. These data suggest the dependence ofboth HSV-1 and Ad2 replication on the samecell function.
• 中文關鍵字： --
• 英文關鍵字： --