- 作者: Takashi Angata
- 作者服務機構: 1. Institute of Biological Chemistry, Academia Sinica, 128, Section 2, Academia Road, Nankang District, Taipei, Taiwan
- 中文摘要:
- 英文摘要:
Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is considered to be a potential therapeutic target for osteoporosis. Recent studies revealed unexpected roles of Siglec-15 in microbial infection and the cancer microenvironment, expanding the potential pathophysiological roles of Siglec-15. Chemical biology has advanced our understanding of the nature of Siglec-15 ligands, but the exact nature of Siglec-15 ligand depends on the biological context, leaving plenty of room for further exploration. - 中文關鍵字:
- 英文關鍵字: Siglec-15, Sialic acid, Osteoclast, Macrophage, Cancer, Microbial infection