- 作者: 李水盛; 楊玲華; 王光昭
- 作者服務機構: 國立臺灣大學醫學院藥學系
- 中文摘要: 固醇化合物cycloartenol,24-methylenecycloaranol,lanosterol經由微生物Mycobacterium sp.(NRRL B-3805)轉變反應後,分離並鑑定出五種類固醇產物。此些代謝產物與其起始物之化學構造相差甚大,吾等應用二維核磁共振技術澄清其架構,並由nOe技術確立其立體化學結構。
- 英文摘要: Microbial transformations of cycloartenol, 24-methylenecycloartanol and lanosterol with Mycobac-terium sp. (NRRL B-3805) resulted in the isolation and characterization of five, steroids. Details ofthe tremendous structural modifications of these metabolites from their parent compounds were clarifiedby 2D nmr techniques. The stereochemistry of these novel metabolites was determined by nOe studies.
- 中文關鍵字: microbial transformation; oryzanol; 2D nmr; nOe.
- 英文關鍵字: --