- 作者: C.J Liu, J.H. Kao, P.J. Chen, M.Y. Lai, D.S. Chen
- 作者服務機構: Department of Internal Medicine, Graduate Institute of Clinical Medicine, Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan, ROC
- 中文摘要: --
- 英文摘要: tween 17 patients born in Taiwan (6 adw/genotype B, 2adw/genotype C, 1 adw/genotype F and 8 adr/genotypeC) and 14 patients born in mainland China (5 adw/geno-type B, 2 adw/genotype C and 7 adr/genotype C). Ourresults indicate that in Taiwan, most HBVs of serotypeadw are genotype B, and all HBVs of serotype adr aregenotype C. Patientswith origins in mainland China havea higher proportion of serotype adr/genotype C infec-tion.Subtypes of hepatitis B virus (HBV) have specific geo-graphic distributions and can serve as epidemiologicalmarkers. The relationship of HBV serotypes and geno-types in Taiwan and their correlation with the domicilesof origin in 122 patients with chronic HBV infection wereinvestigated. The serotype of HBV was determined bycomparing the surface gene encoding amino acids 22-148 of the major surface protein with published se-quences. Genotyping of HBV was performed by poly-merase chain reaction-restriction fragment length poly-morphism. Serotype adwaccounted for 70%(85/122) ofall HBVs, with the remaining belonging to serotype adr.All adrHBVs were genotype C, regardless of the patient'sdomicile. Of the 85 adw HBVs, 69 (81%) were genotypeB, 10 (12%) were genotype C, 5 (6%) were genotype Fand only 1 (1%) was genotype A. In the 31 patients origi-nating from mainland China, the prevalence of adr/geno-type C was higher than in the 91 Taiwanese patients (15/31 vs. 22/91; p<0.05). The distribution of the HBV sero-types and genotypes was not significantly different be-
- 中文關鍵字: --
- 英文關鍵字: Hepatitis B virus, Serotype, Genotype, Surface gene, Molecular epidemiology