- 作者: Cicero Lee-Tian Chang; Hui-Kai Kuo; Shu-Lin Chang; Yi-Ming Chiang; Tsung-Han Lee; Wen-Mein Wu; Lie-Fen Shyur; Wen-Chin Yang
- 作者服務機構: 1 Institute of Bio Agricultural Sciences, Academia Sinica, Taiwan, ROC; 2 Department of Life Sciences, National Chung Hsing University, Taiwan, ROC; 3 Department of Biological Science and Technology, National Chiao Tung University, ROC; 4 Department of Nutrition and Food Sciences, Fu Jen Catholic University, ROC; These authors equally contributed to this work
- 中文摘要: --
- 英文摘要: Bidens pilosa is claimed to be useful for immune or anti-inflammatory disorders; however, little scientific evidence has been published concerning its function. In this paper, immune disease mouse models were used to study the function of a butanol fraction of B. pilosa. We demonstrated treatment with the butanol fraction of B. pilosa ameliorated Th1 cell-mediated autoimmune diabetes in nonobese diabetic (NOD) mice but caused deterioration of Th2 cell-mediated airway inflammation induced by ovalbumin (OVA) in BALB/c mice. We next showed that Th2 cytokines (IL-4 and/or IL-5) increased but Thl cytokine (IFN-γ) decreased following injections with the butanol fraction of B. pilosa in both mouse strains. Accordingly, Th2 cytokine-regulated IgE production in mouse serum increased following treatment with this fraction. Finally, we found that the butanol fraction of B. pilosa inhibited Thl cell differentiation but promoted Th2 cell differentiation. Taken together, the butanol fraction of B. pilosa has a dichotomous effect on helper T cell-mediated immune disorders, plausibly via modulation of T cell differentiation.
- 中文關鍵字: --
- 英文關鍵字: airway inflammation, Bidens, diabetes, helper T cells (Th)