• 作者： 蘇美貴; 于秀
• 作者服務機構： 國立陽明醫學院藥理學科
• 中文摘要： 本實驗觀察懷孕母鼠以Diazepam處理對子代腦中鳥氨基酸脫羧基酵素發育型態與其一般生長的影響。懷孕的Spra-gue-Dawley大白鼠，在懷孕第14天到20天，每天以胃管給予120 mg/kg的Diazepam，然後測其子代在懷孕後期與出生後腦中鳥氨基酸脫羧基酵素的活性與其體重，發現Diazepam對整個腦中此酵素的成長型態無多大改變，但確實抑制出生前與出生後4小時時的鳥氨基酸脫羧基酵素活性，故可能抑制早期腦的發育。處理組的新生鼠在出生後6小時或更大年齡時，具有與對照組相同的鳥氨基酸脫羧基酵素活性，又知腦鳥氨基酸脫羧基酵素後期的發育型態與腦中兒茶酚氨系統成長有密切關係，故此種處理似對腦中兒茶酚氨系統無影響。處理組的子代其一般的生長都遲緩，他們的體重都較對照組低許多，由此結果，更進一步證實Diazepam或其他的Benzodiazepines用於孕婦時需特別謹慎。
• 英文摘要： The prenatal treatment of diazepam on the developmental pattern of brain ornithine decarboxylaseand the general growth of offspring were studied. Diazepam (120 mg/kg/day) was administered orally topregnant Sprague-Dawley rats from day 14 to day 20 of gestation. The activity of brain ornithine decar-boxylase and body weight of the offspring were measured from the late fetal stage to the early postnatalstage. It was found that diazepam inhibited both the prenatal and 4-hour postnatal ornithine decarboxylaseactivities, though the general maturation pattern of the enzyme in the brain was not much altered. It mayindicate that diazepam inhibits early brain development. The enzyme activity fell off as it reached matura-tion. Prenatal treated neonates of 6-hour or older age group had the normal activities of brain ornithinedecarboxylase. The general growth of the treated offspring was substantially retarded. Their body weightswere very much lower than the control offspring. The results of the present study is an additional evidencethat diazepam and other benzodiazepines should be used with great care in pregnant women.
• 中文關鍵字： diazepam; ornithine decarboxylase
• 英文關鍵字： --