- 作者: --
- 作者服務機構: Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 11562, Egypt
- 中文摘要: 4-(4-Acetylphenylamino)cycloocteno[4,5]thieno[2,3-d]pyrimidine (4) was prepared and condensed with certain aldehydes, phenylhydrazine, malononitrile to obtain 5a-d, 6 and 7, respectively. 4-Hydrazino & 4-substituted amino derivatives of 2-arylcycloocteno[4,5]thienopyrimidines 10a-c & 11a-i were synthesized. Cyclization of the hydrazino compounds 10a-c with orthoalkanoate esters or the arylidene derivatives 12a-c with bromine in acetic acid afforded the fused triazolo system 13a-i. Reaction of the hydrazino compound 10c with acetic anhydride gave 15 while the reaction of 10b,c with acid chlorides gave 16a-d. Furthermore, the tetrazolothienopyrimidines 17a-c were synthesized. Some of the newly synthesized compounds were tested for their antimicrobial activity.
- 英文摘要: --
- 中文關鍵字: Thienopyrimidines; Triazolothienopyrimidines; Tetrazolo thienopyrimidines; Synthesis; Antibacterial activity.
- 英文關鍵字: --