- 作者: Pleiades T. Inaoka, Masato Shono, Mishio Kamada and J. Luis Espinoza
- 作者服務機構: 1.Department of Physical Therapy, School of Health Sciences, Kanazawa University, Kodatsuno, Kanazawa 577-8502, Japan 2.Faculty of Medicine, Kindai University, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka 577-8502, Japan 3.Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka 577-8502, Japan
- 中文摘要:
- 英文摘要:
Sarcoidosis is a rare inflammatory disease characterized by the development of granulomas in various organs, especially in the lungs and lymph nodes. Clinics of the disease largely depends on the organ involved and may range from mild symptoms to life threatening manifestations. Over the last two decades, significant advances in the diagnosis, clinical assessment and treatment of sarcoidosis have been achieved, however, the precise etiology of this disease remains unknown. Current evidence suggests that, in genetically predisposed individuals, an excessive immune response to unknown antigen/s is crucial for the development of sarcoidosis. Epidemiological and microbiological studies suggest that, at least in a fraction of patients, microbes or their products may trigger the immune response leading to sarcoid granuloma formation. In this article, we discuss the scientific evidence on the interaction of microbes with immune cells that may be implicated in the immunopathogenesis of sarcoidosis, and highlight recent studies exploring potential implications of human microbiota in the pathogenesis and the clinical course of sarcoidosis. - 中文關鍵字:
- 英文關鍵字: Sarcoidosis, Granulomas, Microbiota, Dysbiosis, Autoimmune disease, Host-microbe interactions