- 作者: 王志偉; 李宏昌; 黃志達
- 作者服務機構: 國立中山大學化學研究所
- 中文摘要:
本文是合成多種化合物以證實運用抗癌活性機構設計抗癌藥物是極具潛力的。
1. 6-氯-2-甲氧-9-三乙烷四胺基氮?及2-(2-(4-咪唑基)乙醯胺)-5-(2-?嗯基)?吩-鐵錯化合物
,可造成去氧核糖核酸股斷裂。
2. 雙嵌入化合物,顯現藥效的增加。
3. 次樸?-鈷單氮?化合物,可運用於光力化學療法。
4. (Z,Z) 3,6-雙(2,5-二甲氧苯甲亞基)2,5-二氧? 化合物,可抑制細菌生長,其形式是與細菌的去氧核
糖核酸烷基化,此機構與沙弗拉黴素的抗癌機構類似。
比 - 英文摘要: The potential applications of the mechanism of action based on the design of anticancer agentsare demonstrated by the synthesis of(i) 6-chloro-2-methoxy-9-triethylene-tetraminoacridine and 2-(2-(4-imidazolyl)ethylamido)-5-(2-thienyl) thiophene iron complexes which cause deoxyribonucleic acidstrand breaks, (ii) a bis-intercalative model which showed improved drug efficacy, (iii) a deuteroporphyrin-cobalt monoacridine model for photodynamic chemotherapy and(iv) (Z,Z) 3,6-bis(2,5dimethoxybenzyli-dene)-2,5dioxopiperazine, which inhibits bacteria growth by a proposed alkylation of deoxyribonucleicacids which impaired its functions, similar to that proposed for saframycin antitumor antibiotics.
- 中文關鍵字: drug design; DNA binding; DAN scissioning; reversible oxygen binders; improved drug efficacy; photodynamic Chemotherapy; alkylating agents
- 英文關鍵字: --