- 作者: Tsan Liu Arnold Stern L. Jackson Roberts Jason D. Morrow
- 作者服務機構: Department of Medical research, Yuan's General Hospital, Kaohsiung, Taiwan, Department of Pharmacology. New York University of Medicine, New York, N.Y., and Departments of Mediclne and Pharmacology, Vanderbilt Universlty School of medicine, Nashville, tenn., USA
- 中文摘要: --
- 英文摘要: The isoprostanes(IsoPs)are a unique series of prosta-glandin-like compounds formed in vivo from the freeradical-catalyzed peroxidation of arachidonic acid. Thisreview summarizes our current knowledge regardingthese compounds. Novel aspects of the biochemistryand bioactivity of IsoPs are detailed and methods bywhich these compounds are analyzed are discussed. Aconsiderable portion of this review deals with the utilityof measuring IsoPs as markers of oxidant injury inhuman diseases particularly in association with risk fac-tors that predispose to atherosclerosis, a condition inwhich excessive oxidative stress has been causally im-plicated.
- 中文關鍵字: --
- 英文關鍵字: Isoprostane. Lipid. Peroxidation. Eicosanoid. Free radical