• 作者： 鄭葳; 高承亨; 丁文華; 陳光耀; 姜必寧
• 作者服務機構： 私立東海大學生物學研究所; 榮民總醫院治癌中心; 榮民總醫院心臟內科
• 中文摘要： 本研究係利用光學及電子顯微鏡來探討C3H雄性小鼠腦部經放射線照射後一個月至十二個月時，其心臟血管在構造
  上的變化。四個月大的小鼠給予 8 Gy 及 20 Gy 單一劑量腦部照射。照射後六個月時，心肌之退化現象開始顯現，而至
  第十二個月時，退化及病變現象更趨嚴重。退化病變現象包括區域性心肌解離，心肌微纖維消失，類溶?體出現，及心
  肌間隔纖維化產生。冠狀動脈之退化現象發生於照射後十二個月時，主要病變包括平滑肌退化，纖維化及細胞碎片，類
  溶?體，基質物的堆積。定量形態測定法分析結果顯示未經照射及偽裝照射，之小鼠冠狀動脈平滑肌退化體積百分比分
  別為13.2%及13.3%。相對的經 20 Gy 照射之小鼠，此體積比變為18.9%, P<0.05.T
• 英文摘要： This study was conducted to investigate the sequential structural changes in the hearts of C3H malemice 1 t0 12 months arter brain irradiation. A single brain dose or 8 or 20 gamma Gy was given tothe animals at 4 months of age. Degenerative changes in the heart occurred, firstly at 6 months afterirradiation, and became progressively more severe at 12 months. The cardiac muscle showed areas of focalmyofibrillolysis, myofibrillar degeneration with loss of entire myofibrils, the presence of lysosomal-likebodies, and interstitial fibrosis. Coronary artery degeneration was also found at 12 months after irradia-tion; the major changes included smooth muscle degeneration with fibrosis, and the accumulation ofdebris and extracellular matrix. Quantitative analysis indicated that the degeneration of the arterial smoothmuscle after 20 Gy irradiation (18.9%) was significantly higher than that of the unirradiated control(13.2%), and shammed control (13.3%) groups, p＜0.05.
• 中文關鍵字： heart; brain-irradiation; ultrastructure
• 英文關鍵字： --