- 作者: 林志峰, 黃萱蓉, 郭耀豪, 吳明忠
- 作者服務機構: Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
- 中文摘要: Among the three series of complicated combinatory enediynes, 3a~d were more active than 2a~c and 4a~b, in which 3a~b showed equally inhibitory activity against the growth of Hepa59T/VGH, KB and Hela with mean IC50 values lower than 10 μg/mL. Compounds 2a and 3b exhibited the most potent inhibitory activity against the growth of Hela cells for 4.39 μg/mL. Derivative 3d displayed the greatest ability against the growth of Hepa59T/VGH cell lines for 6.95 μg/mL, while 3a showed more cytotoxic to KB cells than other analogs. Conjugates 2a-c presented better responses than 3a-d for the DNA cleavage assay of supercoiled ΦX174.
- 英文摘要: --
- 中文關鍵字: Enediyne; Antitumor; Propargyl sulfone.
- 英文關鍵字: --