- 作者: Joost Haasnoot Daniel Cupac Ben Berkhout
- 作者服務機構: Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- 中文摘要: --
- 英文摘要: RNA interference(RNAi)is a sequence-specific gene-silencing mechanism in eukaryotes, which is believed tofunction as a defence against viruses and transposons.Since its discovery, RNAi has been developed into awidely used technique for generating genetic knock-outsand for studying gene function by reverse genetics.Additionally, inhibition of virus replication by means ofinduced RNAi has now been reported for numerousviruses, including several important human pathogenssuch as human immunodeficiency virus type 1,hepatitisC virus, hepatitis B virus, dengue virus, poliovirus andinfluenza virus A. In this review, we will summarize thecurrent data on RNAi-mediated inhibition of virus repli-cation and discuss the possibilities for the developmentof RNAi-based antiviral therapeutics.
- 中文關鍵字: --
- 英文關鍵字: RNA interference. siRNA. Virus. Replication