• 作者： Wei-Yu Chi, Yen-Der Li, Hsin-Che Huang, Timothy En Haw Chan, Sih-Yao Chow, Jun-Han Su, Louise Ferrall, Chien-Fu Hung & T.-C. Wu
• 作者服務機構： 1.Department of Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, USA 2.Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA 3.Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, MD, USA 4.Department of Oncology, Johns Hopkins University, Baltimore, MD, USA 5.Department of Pathology, Johns Hopkins University, Baltimore, MD, USA 6.Department of Urology, Medical Center, University of Freiburg, Freiburg, Germany 7.Downstream Process Science, EirGenix Inc., Zhubei, Hsinchu, Taiwan R.O.C. 8.Faculty of Biology, University of Freiburg, Freiburg, Germany 9.International Max Planck Research School for Immunobiology, Epigenetics and Metabolism (IMPRS-IEM), Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany 10.Physiology, Biophysics and Systems Biology Graduate Program, Weill Cornell Medicine, New York, NY, USA 11.The Johns Hopkins Medical Institutions, CRB II Room 309, 1550 Orleans St, MD, 21231, Baltimore, USA 12.Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
• 中文摘要：
• 英文摘要：
  Coronavirus Disease 2019 (COVID-19) has been the most severe public health challenge in this century. Two years
  after its emergence, the rapid development and deployment of efective COVID-19 vaccines have successfully con‑
  trolled this pandemic and greatly reduced the risk of severe illness and death associated with COVID-19. However, due
  to its ability to rapidly evolve, the SARS-CoV-2 virus may never be eradicated, and there are many important new top‑
  ics to work on if we need to live with this virus for a long time. To this end, we hope to provide essential knowledge
  for researchers who work on the improvement of future COVID-19 vaccines. In this review, we provided an up-to-date
  summary for current COVID-19 vaccines, discussed the biological basis and clinical impact of SARS-CoV-2 variants and
  subvariants, and analyzed the efectiveness of various vaccine booster regimens against diferent SARS-CoV-2 strains.
  Additionally, we reviewed potential mechanisms of vaccine-induced severe adverse events, summarized current stud‑
  ies regarding immune correlates of protection, and fnally, discussed the development of next-generation vaccines.
• 中文關鍵字：
• 英文關鍵字： COVID-19, Vaccine, Immunity, Variant, SARS-CoV-2