- 作者: Chi-Chao Yin; Kuang-Tse Huang
- 作者服務機構: Department of Chemical Engineering, National Chung Cheng University, Chia-Yi, 621, Taiwan
- 中文摘要: --
- 英文摘要: The oxidation of low density lipoprotein (LDL) as a key event in atherosclerosis suggests that antioxidant interventions may reduce the risk of atherosclerosis. However, the better strategies among antioxidant remedies for atherosclerosis remains difficult to be determined. Here, we show that oxidized LDL increases the steady-state level of intracellular hydrogen peroxide through stimulating the protein expressions of Noxl and Cu/Zn superoxide dismutase (SOD) in human aortic smooth muscle cells (SMCs). The intracellular content of hydrogen peroxide rather than superoxide is a key modulator for vascular SMC (VSMC) proliferation, implying that without co-expression of catalase, increased Cu/Zn-SOD activity alone may not be beneficial to reduce the growth of VSMC in an atherosclerotic plaque.
- 中文關鍵字: --
- 英文關鍵字: hydrogen peroxide, low density lipoprotein, NAD(P)H oxidase, smooth muscle cells, superoxide, superoxide dismutase