- 作者: --
- 作者服務機構: Department of Chemistry, Bahauddin Zakariya University, Multan 60800, Pakistan
- 中文摘要: An accurate, simple, fast, and cheap spectrophotometric method has been developed for the determination of lisinopril in pharmaceutical pure and dosage forms. The method is based on the reaction of ninhydrin with primary amine present in the lisinopril in the presence of DMF. This reaction produces a greenish blue colored product which absorbs maximally at 600 nm. Beer’s law was obeyed in the range of 10-150 mg/mL with molar absorptivity of 4.083 ’ 103 L mole-1 cm-1. The effects of variables such as temperature, heating time, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were statistically compared with the official potentiometric method.
- 英文摘要: --
- 中文關鍵字: Spectrophotometry; Lisinopril; Ninhydrin; Pharmaceutical formulations.
- 英文關鍵字: --