- 作者: --
- 作者服務機構: Chemistry Department, Faculty of Science, South Valley University, Aswan 81528, Egypt
- 中文摘要: Reaction of 3,5-diaminothiophene-2-carbonitrile derivatives 3a-c with ethoxycarbonylmethyl isothiocyanate and/or N-[bis(methylthio)methylene]glycine ethyl ester led to formation of 7-substituted-8-amino-5-thioxo-6H-imidazo[1,2:1¢,6¢]pyrimido[5,4-b]thiophene-2(3H)-one derivatives 6a-c and 7-substituted-8-amino-5-(methylthio)imidazo[1,2:1¢,6¢]pyrimido[5,4-b]thiophene-2(3H)-one 7a-c, respectively. Also, the synthetic potential of the b-enaminonitrile moiety in 3a-c has been explored; it proved to be a promising candiate for the synthesis of 1,6-disubstituted-2,4-diamino-7,8-dihydro-8-oxopyrrolo[1,2-a]thieno[2,3-e]pyrimidine derivatives 10a-f and pyrido[2¢,3¢:6,5]pyrimido[3,4-a]benzimidazole derivatives 12a,b.
- 英文摘要: --
- 中文關鍵字: Active methylene; 3,5-Diaminothiophene; Bromoacetyl bromide.
- 英文關鍵字: --