- 作者: Vijendra K. Singh, Sheren X. Lin, Elizabeth Newell, Courtney Nelson
- 作者服務機構: Department of Biology and Biotechnology Center, Utah state University, Logan, Utah, USA
- 中文摘要: --
- 英文摘要: for MBP autoantibodies, suggesting a strong associationbetween MMR and CNS autoimmunity in autism. Stem-ming from this evidence, we suggest that an inappro-priate antibody response to MMR, specifical1y the mea-sles component thereof, might be related to pathogene-sis of autism.Autoimmunity to the central nervous system (CNS), es-pecially to myelin basic protein (MBP), may play a causalrole in autism, a neurodevelopmental disorder. Becausemany autistic children harbor elevated levels of measlesantibodies, we conducted a serological study of measles-mumps-rubella (MMR) and MBP autoantibodies. Usingserum samples of 125 autistic children and 92 controlchildren, antibodies were assayed by ELISA or immuno-blotting methods. ELISA analysis showed a significantincrease in the level of MMR antibodies in autistic chil-dren. Immunoblotting analysis revealed the presence ofan unusual MMR antibody in 75 of 125 (60%) autistic serabut not in control sera. This antibody specifically de-tected a protein of 73-75 kD of MMR. This protein band, as analyzed with monoclonal antibodies, was immuno-positive for measles hemagglutinin (HA) protein but notfor measles nucleoprotein and rubella or mumps viralproteins. Thus the MMR antibody in autistic sera de-tected measles HA protein, which is unique to the mea-sles subunit of the vaccine. Furthermore, over 90% ofMMR antibody-positive autistic sera were also positive
- 中文關鍵字: --
- 英文關鍵字: Autoantibodies, Autism, Autoimmunity, Measles virus, Measles-mumps-rubella antibodies, Vaccines