- 作者: El-Kerdawy, M. ; Eisa, H. ; Barghash, A. et al.
- 作者服務機構: Dept. of Medicinal Chemistry, Univ. of Mansoura, Mansoura, Egypt
- 中文摘要: Three new thiosemicarbazides (1a-c) were prepared from N-(4-phenyl-5-(2-thienyl)-1,2,4-triazol-3-yl) mercaptoacetohydrazide. Reaction of (1a-c) with the appropriate phenacyl bromide afforded thiazoline derivatives whereas their reaction with chloroacetic acid or maleic anhydride gave the corresponding thiazolidine derivatives. Cyclodesulfurization of (1a-c) with DCCD in toluene yielded 5-substituted-amino-1,3,4-oxadiazoles, while their dehydration with PPA gave the corresponding 5- substituted-amino-1,3,4-thiadiazoles. Six representative compounds were tested for their in-vitro antimicrobial activity against some pathogenic microorganisms, some of them were proved to be active.
- 英文摘要: --
- 中文關鍵字: Substituted Thiosemicarbazides; Thiazolines; Thiazolidines; 5-Substituted-Amino-1,3,4-Oxadiazoles; 5-Substituted-Amino-1,3,4-Thiadiazoles
- 英文關鍵字: 氨基硫衍生物;二氫唑;四氫唑;5-取代基-氨基-1;3;4-氧二唑;5-取代基-氨基-1;3;4-硫代二唑