- 作者: Ling-Yi Wu; Jain-Fang Chen; Pao-Luh Tao; Eagle Yi-Kung Huang
- 作者服務機構: Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Co-administration of dextromethorphan (DM) with morphine during pregnancy and
throughout lactation has been found to reduce morphine physical dependence and tolerance in
rat offspring. No evidence was presented, however, for the effect of DM co-administered with
morphine during pregnancy on morphine-induced reward and behavioral sensitization
(possibly related to the potential to induce morphine addiction) in morphine-exposed
offspring. Conditioned place preference and locomotor activity tests revealed that the p60
male offspring of chronic morphine-treated female rats were more vulnerable to
morphine-induced reward and behavioral sensitization. The administration of a low dose of
morphine (1 mg/kg, i.p.) in these male offspring also increased the dopamine and serotonin
turnover rates in the nucleus accumbens, which implied that they were more sensitive to
morphine. Co-administration of DM with morphine in the dams prevented this adverse effect
of morphine in the offspring rats. Thus, DM may possibly have a great potential in the
prevention of higher vulnerability to psychological dependence of morphine in the offspring
of morphine-addicted mothers. - 中文關鍵字: --
- 英文關鍵字: --