- 作者: --
- 作者服務機構: Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
- 中文摘要: Hydrolysis of ethyl 3-amino-4-aryl-cycloalka[e]thieno[2,3-b]pyridine-2-carboxylates (3a-d) gave the corresponding o-aminocarboxylic acids 4a-d. Heating the latter compounds (4a-d) with acetic anhydride furnished the oxazinone derivatives 5a-d which, in turn, underwent recyclization reaction to give the corresponding pyrimidinones 6a-d upon treatment with ammonium acetate in acetic acid. Reaction of 3-amino-4-aryl-cycloalka[e]thieno[2,3-b]pyridine-2-carboxamides (3f,h) with triethyl orthoformate gave pyrimidinone derivatives 7a,b. Reaction of 3-amino-4-phenyl-cycloalka[e]thieno[2,3-b]pyridine-2-carboxamides 3e,h with aromatic aldehydes furnished tetrahydropyridothienopyrimidinones 8a-d. Chlorination of 7a,b and 6a-d by using phosphorous oxychloride produced 4-chlorocycloalka[5¢,6¢]pyrido[3¢,2¢:4,5]thieno[3,2-d]pyrimidine derivatives 9a-f which were used as key intermediates in the synthesis of several new cycloalkapyridothienopyrimidines 10a-f~14a-f. Moreover, some cycloalkapyridothienotriazinones 15a,b-17a,b were synthesized.
- 英文摘要: --
- 中文關鍵字: Cycloalkathienopyridines; Cycloalkapyridothienooxazinones; Cycloalkapyridothienopyrimidines; Cycloalkapyridothienotriazinones.
- 英文關鍵字: --