• 作者： 謝明村; 陳和昌; 許博厚; ?谷健
• 作者服務機構： 中國醫藥學院中國藥學研究所; 日本東京醫學科大學藥理學教室
• 中文摘要： 著者等於前報曾報告我國古方“酸棗仁湯”是一個很好的抗焦慮藥物。為探討酸棗仁湯之作用機轉，吾等研究其對於大白鼠行為及中樞單胺濃度之影響。本研究結果發現酸棗仁湯可以有意義地（1）延長－pentylenetetrazol或picrotoxin 所引起陣攣性驚厥到強直性驚厥之時間，（2）延長Hexobarbital所引起之睡眠時間，（3）減少自發運動量，（4）增加由α-MT所引起運動量抑制作用，（5）減少由Levodopa加Benserazide所引起自發運動量之亢進作用，與（6）減少中樞腦內HVA，VMA與5-HIAA之濃度，但對於中樞腦內DA，NA與5 -HT則無影響。由以上之結果顯示，酸棗仁湯之鎮靜、抗痙攣作用，與降低中樞單胺之轉換速率與兒茶胺系統之活性有關。
• 英文摘要： Previously, it was fcund that the ancient Chinese remedy of Suanzaorentang could be a promisinganxiolytic drug (Chen and Hsieh, 1985a, Chen and Hsieh, 1985b). To understand the mechanism of theaction of Suanzaorentang, the effects of Suanzaorentang on behavior changes and central monoamines andtheir metabolites were studied in rats. It was found that Suanzaorentang significantly (1) prolonged theperiod from the onset of clonic to tonic convulsions induced by pentylenetetrazol or picrotoxin, (2) pro-longed the sleep duration induced by hexobarbital, (3) reduced locomotor activity, (4) enhanced the hy-pomotility induced by α-MT, (5) reduced the locomotor stimulation produced by levodopa plus bensera-zide，and (6) reduced central HVA, VMA, and 5-HIAA, but had no significant effects on central DA, NA,and 5-HT. These facts implied that Suanzaorentang decreased the turnover rate of central monoamines andcentral catecholaminergic activity.
• 中文關鍵字： Suanzaorentang; Monoamines
• 英文關鍵字： --