• 作者： 曾琇真; 徐治平
• 作者服務機構： 私立淡江大學數學研究所; 國立臺灣大學化學工程學系
• 中文摘要： 在探討因輻射線引發之DNA雙股斷裂後修復行為的過程中常被忽略的一個問題是：DNA雙股上正常的位置在受到輻射線照射後瞬間是處於何種狀態？本文中我們提出一個混合的動態模式，亦即，修復過程是由一個漸進的程序與一個瞬間達成的程序組合而成。簡言之，所提出的模式整合了文獻中現有的動力學模型。我們證明了不同的模式可能會導至相同的預測結果。因此，在實驗數據的分析與解釋上必須特別謹慎，以避免獲得錯誤的結論。
• 英文摘要： A problem often overlooked in the study of the repair of radiation-induced DNA double-strandbreaks (DSBs) is the question of what the status of a regular site is in the DNA duplex immediately aftera radiation treatment. Here, we suggest a mixed repair mechanism which consists of a gradual processand an instantaneous process. A comparison of the present kinetic model with those which have appearedin the literature shows that the former is a generalization of the latter. We have shown that differentrepair mechanisms may lead to equivalent mathematical representations. Therefore, care must be takenin interpreting the repair mechanism on the basis of the experimentally observed transient number of DSBs.
• 中文關鍵字： radiation-induced DNA DSB; repair mechanism of DNA; kinetic model
• 英文關鍵字： --