- 作者: Jin-Ying Lu; Kuo-Chin Huang; Lin-Chau Chang; Ying-Shing Huang; Yu-Chiao Chi; Ta-Chan Su; Chi-Ling Chen; Wei-Shiung Yang
- 作者服務機構: Department of Laboratory Medicine, National TaiwanUniversity Hospital, Taiwan, ROC; Department of Internal Medicine, National Taiwan UniversityHospital, ROC; Graduate Institute of Clinical Medicine, College of Medicine,National Taiwan University, Taiwan, ROC
- 中文摘要: --
- 英文摘要: Adiponectin is one of the most thoroughlystudied adipocytokines. Low plasma levels of adiponectinare found to associate with obesity, metabolic syndrome,diabetes and many other human diseases. From animalexperiments and human studies, adiponectin has beenshown to be a key regulator of insulin sensitivity. In thisarticle, we review the evidence and propose that hypoadiponectinemiais not a major cause of obesity. Instead, itis the result of obesity-induced insulin resistance in theadipose tissue. Hypo-adiponectinemia then mediates themetabolic effects of obesity on the other peripheral tissues,such as liver and skeletal muscle and may also exert somedirect effects on end-organ damage. We propose thatdeciphering the molecular details governing the adiponectingene expression and protein secretion will lead us tomore comprehensive understanding of the mechanisms ofinsulin resistance in the adipose tissue and provide us newavenues for the therapeutic intervention of obesity andinsulin resistance-related human disorders.
- 中文關鍵字: --
- 英文關鍵字: Adiponectin; Obesity; Insulin resistance; Adipcytokines; Metabolic syndrome