- 作者: 林翠華 ; 林山陽
- 作者服務機構: 榮民總醫院醫學研究部
- 中文摘要: W/O/W type multiple emulsions were prepared by two step emulsification procedures using an oily lymphographic agent, lipiodol, as an inner oil phase and Pluronic F-68 as a hydrophilic emulsifier contained in the outer aqueous phase. Span 80, Pluronic L-64 and HCO-60 were used as emulsifiers incorporating them into the inner oil phase. The phase volume of the inner and outer aqueous phases and the yield of the w/o/w type multiple emulsions were studied. The dissolution behaviour of the w/o/w type multiple emulsions were determined by a dialysis method employing cellulose tubing. The effect of emulsifier type and the amount of HCO-60 on the stability and prolonged release behavior of the w/o/w type multiple emulsions with or without lecithin, was also examined. The results indicate the HCO-60 is a better emulsifier than Span 80 or Pluronic L-64. Its use improves the stability and the prolonged release behavior of w/o/w type multiple emulsions.
- 英文摘要: --
- 中文關鍵字: Encapsulation; Emulsion; Prolonged Release
- 英文關鍵字: 包以被膜;乳劑;延長釋出