- 作者: S Patyar, R Joshi, D S Prasad Byrav, A Prakash, B Medhi, B K Das
- 作者服務機構: Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
- 中文摘要: --
- 英文摘要:
Resistance to conventional anticancer therapies in patients with advanced solid tumors
has prompted the need of alternative cancer therapies. Moreover, the success of novel
cancer therapies depends on their selectivity for cancer cells with limited toxicity to
normal tissues. Several decades after Coley’s work a variety of natural and genetically
modified non-pathogenic bacterial species are being explored as potential antitumor
agents, either to provide direct tumoricidal effects or to deliver tumoricidal molecules.
Live, attenuated or genetically modified non-pathogenic bacterial species are capable of
multiplying selectively in tumors and inhibiting their growth. Due to their selectivity for
tumor tissues, these bacteria and their spores also serve as ideal vectors for delivering
therapeutic proteins to tumors. Bacterial toxins too have emerged as promising cancer
treatment strategy. The most potential and promising strategy is bacteria based genedirected
enzyme prodrug therapy. Although it has shown successful results in vivo yet
further investigation about the targeting mechanisms of the bacteria are required to make
it a complete therapeutic approach in cancer treatment. - 中文關鍵字: --
- 英文關鍵字: --