- 作者: Sheng-Wen Huang, Dayna Cheng and Jen-Ren Wang
- 作者服務機構: 1. National Mosquito-Borne Diseases Control Research Center, National Health Research Institutes, Tainan, Taiwan 2. National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan 3. Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 4. Center of Infectious Disease and Signaling Research, National Cheng Kung University, One, University Road, Tainan, 701, Taiwan 5. Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
- 中文摘要:
- 英文摘要:
As a neurotropic virus, enterovirus A71 (EV-A71) emerge and remerge in the Asia-Pacific region since the 1990s, and has continuously been a threat to global public health, especially in children. Annually, EV-A71 results in hand-foot-and-mouth disease (HFMD) and occasionally causes severe neurological disease. Here we reviewed the global epidemiology and genotypic evolution of EV-A71 since 1997. The natural selection, mutation and recombination events observed in the genetic evolution were described. In addition, we have updated the antigenicity and virulence determinants that are known to date. Understanding EV-A71 epidemiology, genetic evolution, antigenicity, and virulence determinants can expand our insights of EV-A71 pathogenesis, which may benefit us in the future. - 中文關鍵字:
- 英文關鍵字: Enterovirus A71, Epidemiology, Evolution, Recombination, Virulence, Antigenicity