- 作者: Li-Ling Chiu; Shih-Wei Chou; Yu-Min Cho; Hsin-Yi Ho; John L. Ivy; Desmond Hunt; Paulus S. Wang; Chia-Hua Kuo
- 作者服務機構: Laboratory of Exercise Biochemistry, Taipei Physical Education College, Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, and Department of Physiology, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Kinesiology, University of Tezas, Austin, Tex., and National Institute of Diabetes and Digestive and Kideny Diseases, National Institutes of Health, Bethesda, Md., USA
- 中文摘要: --
- 英文摘要: We compared the chronic effect of intermittent hypoxiaand endurance training on the glucose tolerance andGLUT4 protein expression in rat skeletal muscle. Thirty-two Sprague-Dawley rats were matched for weight andassigned to one of the following four groups: control,endurance training, hypoxia, or hypoxia followed byendurance training. Hypoxic treatment consisted ofbreathing 14% O2 for 12 h/day under normobaric condi-tions, and the training protocol consisted of making ani-mals swim 2 times for 3 h/day. At the end of the 3rdweek, an oral glucose tolerance test (OGTT) was per-formed 16 h after treatments. At the end of the 4th week,GLUT4 protein, mRNA, and glycogen storage in skeletalmuscle were determined. Endurance training significant-1y improved OGTT results. Glycogen content and GLUT4protein expression in the plantaris and red gastrocnemi-us, but not in the soleus or white gastrocnemius mus-cles, were also elevated. Chronic intermittent hypoxiaalso improved OGTT results, but did not alter GLUT4protein expression. Additionally, hypoxia followed byexercise training produced significant increases inGLUT4 protein and mRNA in a greater number of mus-cles compared to endurance training alone. Both exer-cise training and hypoxia significantly reduced bodymass, and an additive effect of both treatments wasfound. In conclusion, chronic intermittent hypoxia im-proved glucose tolerance in the absence of increasedGLUT4 protein expression. This treatment facilitated theexercise training effect on muscle GLUT4 expression andglycogen storage. These new findings open the possibili-ty of utilizing intermittent hypoxia, with or without exer-cise training, for the prevention and clinical treatment oftype 2 diabetes or insulin resistance.
- 中文關鍵字: --
- 英文關鍵字: --