- 作者: --
- 作者服務機構: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
- 中文摘要: Twelve novel primary (4a-c, 5a-c) and secondary (4d-f, 5d-f) benzenesulfonamides bearing 2,5-disubstituted-1,3,4-oxadiazole moiety have successfully been prepared by direct chlorosulfonation of phenyl substitutent present on the 2-position of 5-mercapto-1,3,4-oxadiazoles 2a-c and their methylhio derivatives 3a-c using chlorosulfonic acid under anhydrous conditions. Structures of the synthesized compounds were established by their physical and spectral data. Some of the synthesized compounds have been screened in vitro for their antimicrobial and anti-HIV activity; the results were in accordance with SAR.
- 英文摘要: --
- 中文關鍵字: Benzenesulfonamides; 1,3,4-Oxadiazole; Methylthio derivatives; Chlorosulfonation; Antimicrobial and Anti-HIV activity.
- 英文關鍵字: --