- 作者: 李水盛 ; 游碧菁 ; 王光昭
- 作者服務機構: 台灣大學藥學系
- 中文摘要: Ceanothic acid (1) is the major triterpene isolated from Parliurus ramosissimus (Rhamnaceae) which possesses three methyl groups corresponding to the 4,4,14.alpha.- trimethyl groups in lanosterol. Microbial transformation of 1 and its 3-dehydro-2,28- dimethyl ester derivative with Mycobacterium sp. (NRRL B-3805) resulted in the methylation of the carboxylic functions and C-1 epimerization, respectively. Although this work indicates that 1 is not a suitable substrate for 4,4,14.alpha.- tridemethylation, esterification of the carboxylic function and the C-1 epimerization reaction in ceanothic acid and its derivative is the first observation with this microorganism.
- 英文摘要: --
- 中文關鍵字: Ceanothic Acid; Microbial Transformation; Mycobacterium Sp.; Rhamnaceae; Lanosterol; Esterification
- 英文關鍵字: 北美瀉茶酸;微生物轉換作用;分枝桿菌;鼠李科;羊毛硬脂醇;酯化