- 作者: 謝明村; 葉豐次; 陳和昌 林乃女; 陳介甫; 王廷甫
- 作者服務機構: 中國醫藥學院中國藥理研究所及附設醫院; 陽明醫學院藥理學科
- 中文摘要: 知柏八味丸由熟地黃、山茱萸、山藥、牡丹皮、澤瀉、茯苓、知母、黃柏等藥材所組成,在中醫臨床上用來治療多尿、多渴、多飢的病人。而本研究係探討知柏八味丸,BaseⅠ(熟地黃、山茱萸、山藥、牡丹皮),BaseⅡ(澤瀉、茯苓、知母、黃柏)對於Streptozotocin誘發高血糖大白鼠之影響,探討其於四天內血糖濃度、於七星期內血糖濃度、標準口服葡萄糖耐量試驗與肝醣之測定。於標準口服葡萄糖耐量試驗中,使用chlorpropamide及insulin為對照品,比較知柏八味丸之效果。 由實驗結果顯示知柏八昧丸具有降血糖作用、增加葡萄糖利用能力與增加肝醣合成量。因此我們推論知柏八味丸具有增加葡萄糖進入細胞的作用。又BaseⅠ配合BaseⅡ後為八昧丸其降血糖作用增加及毒性減低,可能由於其成分間產生相互作用,此有待進一步探討其成分變化。
- 英文摘要: The ancient Chinese remedy of Paweiwan was used by patients with polyuria, polydipsia, and polyphagia·The present study investigated the hypoglycemic effects of Paweiwan using streptozotocin-induced hypergly-cemic rats. The effects on serum glucose in a 4-day course, in a 7-week course, on the standard oral glucosetolerance test, and on the liver glycogen content were studied. In the glucose tolerance test, chlorpropamideand insulin were used as the positive controls and 0.5% CMC (Carboxymethylcellulose) was used asthe negative control. We found that Paweiwan decreased the baseline glucose concentration, ameliorated the blood glucoseelevation after glucose challenge, and increased liver glycogen content. The results may imply that Paweiwanincreases glucose entrance into cells.
- 中文關鍵字: Pawiwan; streptozotocin
- 英文關鍵字: --