- 作者: 陳基旺 ; 郭季安 ; 盧冠宇
- 作者服務機構: 國防醫學院藥品研究製造所
- 中文摘要: The reaction of 2,5-diamino-4-benzylamino-pyrimidin-6(1H)-one with benzoyl isothiocyanate furnished 2-amino-4-benzylamino-5-(1-(3-benzoylthioureido))-pyrimidin-6(1H)-one(7) in good yield. The title compound was synthesized from compound 7 via a cyclodesulfurative reaction with DCC in DMF at 80.degree.C directly to form 8-benzoylamino-9-benzylguanine which was subsequently treated with 1 N sodium hydroxide.
- 英文摘要: --
- 中文關鍵字: Purine Nucleoside Phosphorylase; Inhibitor; 8-Amino-9-Benzyl-Guanine; Cyclodesulfurization
- 英文關鍵字: 嘌呤核磷酸化;抑制劑;8-氨基-9-苯基-鳥嘌呤;環化脫硫