• 作者： 彭明聰; 蔡錦玲
• 作者服務機構： 國立臺灣大學醫學院生理學科
• 中文摘要： Long-Evans雌鼠分年輕(3-4個月）及年老(19個月以上）兩組。雌鼠卵巢切除後即時皮下移植含有14%，20%或33％雌二醇之矽膠管。就兩組雌鼠比較其對雄鼠之引誘行為及交配行為。脊柱前凸係數(LQ)及脊柱前凸發生率兩組無差別，但對雄鼠之引誘行為之發生率年老組比年輕組低。 腦的前方背部水平面切斷（ARD)後再比較兩組之對雄鼠引誘行為及交配行為。ARD增加年輕雌鼠及年老呈現持久性陰道上皮細胞角化之雌鼠(PVC）之LQ，但對年老呈現持久性乏情期之雌鼠(ANE)之LQ並無影響。ARD亦增加年輕及年老雌鼠對雄鼠引誘行為的發生率。不過此兩種行為ARD後其增強的程度，在年老雌鼠比年輕雌鼠輕微。 以上結果顯示雌鼠高齡時前腦之對雄鼠引誘行為及交配行為的抑制性機能降低而且此機能降低年老雌鼠中ANE鼠比PVC鼠顯著。
• 英文摘要： Female rats of Long-Evans strain were divided into a young group (3 to 4 months of age, mo) andan aged group (over 19 me). Rats were ovariectomized and implanted subcutaneously with 14%, 20% or 33%estradiol benzoate (E2)-cholesterol mixture-filled Silastic capsules. Proceptivity and receptivity were com-pared between young rats and aged rats. There was no age difference in the lordosis quotient (LQ) orin the incidence of lordosis, but the incidence of solicitation was lower in aged rats than in young rats.Proceptivity and receptivity were examined again after anterior roof deafferentation (ARD) of the brain.ARD enhanced LQ in young rats and old prolonged vaginal cornification (PVC) rats but not in old anestrous(ANE) rats. ARD also increased the incidence of solicitation in both young and aged rats. However, theextent of enhancement of these two behaviors was smaller in the aged rats than in the young rats. Theseresults demonstrate that there is decreased inhibitory influence from the forebrain on solicitation and lor-dosis following induction by exogenous estradiol in advancing age and that the disinhibition of lordosisis more prominent in ANE rats than in PVC rats.
• 中文關鍵字： anterior roof deafferentation; lordosis; old female rats; solicitation
• 英文關鍵字： --