- 作者: Wei-Chien Huang and Mien-Chie Hung
- 作者服務機構: Center for Molecular Medicine, China Medical University Hospital, Taichung 40447, Taiwan, R.O.C
- 中文摘要: --
- 英文摘要:
IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two kinase
subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating IκB
proteins during inflammatory and immune responses, the activation of the IKK complex also
responds to various stimuli to regulate diverse functions independently of NF-κB. Although
these two kinases share structural and biochemical similarities, different sub-cellular
localization and phosphorylation targets between IKKα and IKKβ account for their distinct
physiological and pathological roles. While IKKβ is predominantly cytoplasmic, IKKα has
been found to shuttle between the cytoplasm and the nucleus. The nuclear-specific roles of
IKKα have brought increasing complexity to its biological function. This review highlights
major advances in the studies of the nuclear functions of IKKα and the mechanisms of IKKα
nuclear translocation. Understanding the nuclear activity is essential for targeting IKKα for
therapeutics. - 中文關鍵字: --
- 英文關鍵字: Nuclear IKKα, NF-κB, Gene transcription, Tumor progression