• 作者： 吳國良; 李繼源; 沈國樑; 陳華宗; 劉江川
• 作者服務機構： 國防醫學院生物及解剖學科; 三軍總醫院胃腸科; 三軍總醫院外科部; 三軍總醫院麻醉部
• 中文摘要： 本實驗乃仿高選擇性迷走神經切斷術（Highly Selective Vagotomy）胃小彎肌層切開術的改進方法，實施於5組之貓，以Horseradish過氧化氫醇（HRP）神經徑路追蹤法，評估迷走神經分枝是否有再生或再支配情形，同時以光學顯微鏡及電子鏡觀察分析胃黏膜及胃壁細胞（parietal cell）的形態變化，貓在手術後第4，8， 12，16，20週犧牲處理，在第16週以後，發現有少部份的迷走神經再支配於胃本體。胃壁細胞數目、及胃壁細胞與胃黏膜的體積比值，在手術後第4及第12週之間，均為有意義增加。胃壁細胞於電子鏡觀察下其4種類型：刺激型、部份刺激型、回復型、及不分泌型，手術後不分泌型佔大多數，尤其在第4及第12週之間。綜合以上觀察，雖然手術後胃壁細胞數目及體積比值增加，胃小彎肌層切開術可降低胃壁細胞的功能及反應性。
• 英文摘要： A modified, highly selective vagotomy-seromyotomy of the lesser curvature of the stomach wasperformed on five groups of cats. The horseradish peroxidase (HRP) tract-tracing method was used todetect the regeneration or reinnervation of vagal nerve branches. Morphological changes to the parietalcells and to the gastric mucosa were also examined by light and electron microscopy. Following surgery,the cats were sacrificed at the fourth, eighth, twelfth, sixteenth and the twentieth week. At the sixteenthweek, partial regeneration of vagal nerve branches was found. Between the fourth and the twelfth weekthere was a significant increase in the number of parietal cells per 0.1 mm-wide of mucosa column and inthe volume fraction of the mucosa made up of parietal cells. Of the four types of parietal cells,"stimulated", "partially stimulated", "returning'’and“resting", the resting type was predominant afterseromyotomy, especially between the fourth and the twelfth week. Based on the above observation,we concluded that the modified lesser-curvature seromyotomy depresses the function and responsiveness ofthe parietal cells despite an increase in their number and in their volume fraction.
• 中文關鍵字： vagotomy; lesser-curvature seromyotomy; parietal cell; horseradish peroxidase(HRP)
• 英文關鍵字： --