- 作者: 鄧巧臨 ; 曹斌 ; 來魯華
- 作者服務機構: 北京巿北京大學化學系
- 中文摘要: In structure-based design of phospholipase A/sub 2/ inhibitors, comparative molecular field analysis is performed on known phospholipase A/sub 2/ (PLA/sub 2/) inhibitors to build a pseudo-receptor map of the enzyme, which is compared to maps from probe searches with proton and methane. The pseudo-receptor map resembled in steric properties to the map from a probe search. Hence known ligands can be used to deduce the shape and chemical properties of the binding site of a receptor. Useful information for drug design can be obtained from such receptor mapping.
- 英文摘要: --
- 中文關鍵字: Phospholipase; Inhibitor; Probe Search; Receptor Mapping; Comparative Molecular Field Analysis
- 英文關鍵字: 磷脂;抑制劑;探針搜尋;受器映射;比較分子場分析