- 作者: Ya-Ping Tsai and Kou-Juey Wu
- 作者服務機構: Institute of Biochemistry & Molecular Biology, National Yang-Ming University, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Hypoxia is an important microenvironmental factor that induces cancer metastasis.
Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the
metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the
crucial mechanisms to cause early stage of tumor metastasis. To have a better understanding
of the mechanism of hypoxia-regulated metastasis, various hypoxia/HIF-1α-regulated target
genes are categorized into different classes including transcription factors, histone modifiers,
enzymes, receptors, kinases, small GTPases, transporters, adhesion molecules, surface
molecules, membrane proteins, and microRNAs. Different roles of these target genes are
described with regards to their relationship to hypoxia-induced metastasis. We hope that this
review will provide a framework for further exploration of hypoxia/HIF-1α-regulated target
genes and a comprehensive view of the metastatic picture induced by hypoxia. - 中文關鍵字: --
- 英文關鍵字: Hypoxia, Hypoxia-inducible factor, Target genes, Metastasis, Epithelial-mesenchymal transition