- 作者: Juan Zou, John A. Parkinson and Peter J. Sadler*
- 作者服務機構: Department of Chemistry, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JJ, UK
- 中文摘要: Reactions of Au(III) with biomolecules are of interest in relation to understanding the mechanism of action of therapeutic gold compounds. NMR investigations of 13C and 15N isotopically-labelled glycine and alanine show that Au(III) induces deamination and subsequent decarboxylation of both amino acids with the same mechanism. For comparison, reactions of Au(III) with sarcosine and the dicarboxylic acid malonic acid were also investigated. The major intermediates and products have been identified.
- 英文摘要: --
- 中文關鍵字: Gold(III) complex; Amino acid; Malonic acid; NMR spectroscopy; Isotope labelling.
- 英文關鍵字: Gold(III) complex; Amino acid; Malonic acid; NMR spectroscopy; Isotope labelling.