- 作者: Jiro Fujimoto; Miki Nishigaki; Masashi Hori; Satoshi Ichigo ; Shigeo Morishita; Teruhiko Tamaya
- 作者服務機構: Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu, Japan
- 中文摘要: --
- 英文摘要: The mechanism of known receptor-mediated androgen effects on the endome- trial stroma was studied in endometrial fibroblasts derived from human uter- us. 17β-Estradiol (E) induced the expressions of androgen receptor (AR) mRNA, and predominantly increased the level of testosterone-binding sites (TBS) in uterine endometrial fibroblasts. The effect on the level of dihydrotes- tosterone-binding sites (DHTBS) was similar but smaller. This result suggests that the AR mRNA expressed might encode TBS, but probably not DHTBS. The TBS level increased by estrogen was down-regulated by testosterone (T)+ E, but the AR mRNA expression increased by E was not down-regulated by E +T in the fibroblasts. Although the synthesis rate of AR was slightly increased (p<0.05) by E alone or E+T, the degradation rate of AR was significantly accelerated (p<0.05) by E+T in the f'ibroblasts. This result suggests that T might stimulate the metabolic rate of TBS, but does not inhibit the synthesis rate of AR mRNA to TBS in endometrial fibroblasts.
- 中文關鍵字: --
- 英文關鍵字: --