• 作者： 陳朝?; 劉華茂; 方懷時
• 作者服務機構： 國立臺灣大學醫學院生理學科
• 中文摘要： 高壓氧在臨床上的應用日廣，但要特別注意其使用的時間及強度，若使用不當，會造成中毒的現象，一般高壓氧毒的研究，大都偏向肺功能及中樞神經方面，但氧壓的昇高應該是全面性的，全身所有的器官都會受到影響－也包括腎臟。在這個實驗我們報告動物遭受4.8大氣壓力的純氧60分鐘及6.8大氣壓力的純氧直到抽筋後，腎功能的改變及恢復的情形。我們發現只有在後面一組的實驗動物才會有腎功能的變異。在高壓氧後4小時的老鼠，利用新陳代謝箱的研究發現，腎臟排除尿素及肌氨酸酐的數量減少，因而該二物質在血漿中的濃度升高；菊澱粉及對氨馬尿酸的血漿清除率也下降；又腎臟對大量食鹽水的排除能力也降低。在高壓氧毒後24小時，這些實驗組都有顯著改善。這個研究得知，高壓氧毒後，腎功能會受到影響，但24小時後腎功能已經接近正常。
• 英文摘要： The after-effects of renal function were studied in rats exposed to hyperbaric oxygen (HBO) ateither 4.8 ATA for 60 min or 6.8 ATA until the onset of convulsions. Only the rats which suffered fromHBO convulsions were found to have alterations in renal function. It was observed that 4 hr after convul-sions, there was a decrease in urinary excretion of urea and creatinine, which resulted in an elevation ofblood urea nitrogen (BUN) and creatinine. Clearances of inulin and p-aminohippuric acid showed a de-crease in the glomerular filtration rate and effective renal blood flow 4 hr after HBO convulsions. Theseparameters nearly returned to normal in 24 hr after convulsions. The renal handling of a large volume ofinfused saline was also retarded 4 hr after HBO convulsions, but by the end of 24 hr after HBO convulsions,it was much improved. Therefore, it was concluded that the renal function was altered after HBO convul-sions, but nearly recovered in 24 hr.
• 中文關鍵字： hyperbaric oxygen; convulsion; oxygen toxicity; renal function
• 英文關鍵字： --