- 作者: Yia-Ping Liu; Yu-Lung Lin; Chia-Hsin Chuang; Yu-Cheng Kao; Shang-Tang Chang; Che-Se Tung
- 作者服務機構: Dept. of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
The study examined the effects of a norepinephrine transporter (NET) inhibitor
reboxetine (RBX) on an attentional performance test. Adult SD rats trained with
five-choice serial reaction time task (5-CSRTT) were administered with RBX (0, 3.0
and 10 mg/kg) in the testing day. Alpha-1 adrenergic receptor antagonist PRA and
alpha-2 adrenergic receptor antagonist RX821002 were used to clarify the RBX effect.
Results revealed that rat received RBX at 10mg/kg had an increase in the percentage
of the correct response and decreases in the numbers of premature response. Alpha-1
adrenergic receptor antagonist Prazosin (PRA) at 0.1mg/kg reversed the RBX
augmented correct responding rate. However, alpha-2 adrenergic receptor antagonist
RX821002 at 0.05 and 0.1 mg/kg dose dependently reversed the RBX reduced
impulsive responding. Our results suggested that RBX as a norepinephrine transporter
inhibitor can be beneficial in both attentional accuracy and response control and
alpha-1 and alpha-2 adrenergic receptors might be involved differently. - 中文關鍵字: --
- 英文關鍵字: --