• 作者： 陳榮基; 黃銀河
• 作者服務機構： 國立臺灣大學醫學院神經科; 國立臺灣大學醫學院生理學科
• 中文摘要： 本實驗用四種癲癇的動物模式來研究針刺治療的效果。根據古籍所載，選用24個穴道，一個或數個穴道同時刺激，使用捻針或電針。 1. 在電擊抽搐閾（6Hz-EST）模式，用0.2 msec, 6Hz的方形波刺激小白鼠兩眼角膜3秒，引發震暈反應。在對照組，86隻動物中，誘發震暈反應的電流強度為0.70 0.22 mA，在針刺處理組80隻中，強度為0.75 0.14 mA。 2. 在最強電擊（60Hz-MES）模式，以0.4 sec, 60Hz, 75 mA的方形電波刺激小白鼠角膜，觀察發生後腿強直反應的動物數。在對照組，115隻中75.7％產生此反應，在針刺組，80隻中77.5％產生此反應。 3. 在局部皮質盤尼西林模式，於貓的大腦軟腦膜下注入盤尼西林，記錄皮質電波。在24隻貓，當不斷的出現棘波甚或癲癇發作波時，施於針刺：在175次針刺中，16次減少棘波，82次增加棘波；在99次針刺中，4次癲癇發作波減少，而79次發作波增加。 4. 在靜注盤尼西林模式，以大量盤尼西林（每公斤一百萬至一百五十萬單位）靜注於20隻貓。在誘發反複棘波甚或癲癇波發作時，施於針刺；在192次針刺中，13次棘波減少，103次增加；在74次針刺中，4次癲癇發作波減少，66次增加 結論：針刺對實驗癲癇，沒有治療效果。反之，有時當癲癇電波相當活躍時，針刺反而有惡化癲癇的危險。
• 英文摘要： The therapeutic effect of acupuncture on epilepsies was evaluated in 4 experimental models. 24acupuncture points were tried. In electroconvulsive threshold model, square wave electrical stimulus of0.2 msec and 6 Hz was applied through a pair of cotton electrodes at the cornea of mice for 3 sec. Thestimulus intensity to induce stun reaction of the mouse was compared. In 86 control animals, the stimulusthreshold was 0.70 0.22 mA. In the acupuncture treated group (N=80), the threshold was 0.75 0.14mA. In maximal electroshock model, the stimulus parameters were 60 Hz, 0.4 sec and 75 mA. The tonicextensor response of the hindlimbs of the mice was observed. 75.7% of the 115 control mice and 77.5%of the 80 acupuncture treated mice were observed to have tonic extensor response. In the focal corticalpenicillin model, penicillin was applied at the subpial space over the exposed cortex of 24 cats. After theappearance of repeated spikes in ECoG, acupuncture was performed. In 175 trials the interictal spikes weredecreased in 16 times, increased in 82 times. In 99 trials during seizures, the ictal activity was decreasedin 4 times, increased in 79 times. In the intravenous penicillin model, high dose penicillin (1,000,000 -1,500,000 U/kg) was given to 20 cats. It induced repetitive spikes and frequently even seizure dischargesin EEG. Acupuncture was then tried. In 192 instances, acupuncture reduced the spikes in 13, increased thespikes in 103 times. In 74 trials during seizures, the ictal activity was suppressed in 4 times and aggravatedin 66 times. It was concluded that acupuncture did not have therapeutic effect on the experimental epilep-sies. On the contrary, when the epileptic discharges were quite active, acupuncture might aggravate theepileptic condition.
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