- 作者: Delong Liu; Lu-Hai Wang
- 作者服務機構: Department of Microbiology, The Mount Sinai School of Medicine, few York, N,Y., USA
- 中文摘要: --
- 英文摘要: Many oncogenes encode protein tyrosine kinases (PTKs). Oncogenic muta- tions of these genes invariably result in constitutive activation of these PTKs. Autophosphorylation of the PTKs and tyrosine phosphorylation of their cellu- lar substrates are essential events for transmission of the mitogenic signal into cells. The recent discovery of the characteristic amino acid sequences, of the src homology domains 2 and 3 (SH2 and SH3), and extensive studies on pro- teins containing the SH2 and SH3 domains have revealed that protein tyro- sine-phosphorylation of PTKs provides phosphotyrosine sites for SH2 bind- ing and allows extracellular signals to be relayed into the nucleus through a chain of protein-protein interactions mediated by the SH2 and SH3 domains. Studies on oncogenes, PTKs and SH2/SH3-containing proteins have made a tremendous contribution to our understanding of the mechanisms for the con- trol of cell growth, oncogenesis, and signal transduction. This review is intended to provide an outline of the most recent progress in the study of signal transduction by PTKs.
- 中文關鍵字: --
- 英文關鍵字: Growth factor; Ligand; Oncogenesis; Phosphotyrosine; Receptor