• 作者： Henry Sung-Ching Wong, Ying-Ju Lin, Hsing-Fang Lu, Wen-Ling Liao, Chien-Hsiun Chen, Jer-Yuarn Wu, Wei-Chiao Chang and Fuu-Jen Tsai
• 作者服務機構： 1. Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan 2. Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan 3. School of Chinese Medicine, China Medical University, Taichung, Taiwan 4. Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan 5. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan 6. Center for Personalized Medicine, China Medical University Hospital, Taichung, Taiwan 7. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan 8. Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan 9. Department of Medical Research, Shuang Ho Hospital, Taipei Medical University , New Taipei City, Taiwan 10. Pain Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan 11. Children’s Hospital of China Medical University, Taichung, Taiwan 12. Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan
• 中文摘要：
• 英文摘要：
  Background
  Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, with only recombinant human growth hormone (rhGH) being available.
  
  Methods
  Herein, starting from the identification of 122 genetic loci related to FSS, we adopted a genetic-driven drug discovery bioinformatics pipeline based on functional annotation to prioritize crucial biological FSS-related genes. These genes were suggested to be potential targets for therapeutics.
  
  Results
  We discovered five druggable subnetworks, which contained seven FSS-related genes and 17 druggable targerts.
  
  Conclusions
  This study provides a valuable drug repositioning accompanied by corresponding targetable gene clusters for FSS therapy.
• 中文關鍵字：
• 英文關鍵字： Genome-wide association study, Familial short stature, Single-nucleotide polymorphism, Pharmacogenomics, Drug repositioning/repurposing