• 作者： 魏健吾; 廖志飛; 莊清堯; 陳介甫; 韓偉
• 作者服務機構： 國立陽明醫學院 神經科學研究所及藥理學科
• 中文摘要： Matrine係由中藥山豆根經分離所得的純化物質；此物質被用來研究對於大白鼠心臟血管系統的影響。當由靜脈注射5 mg至20 mg/kg（體重）此物入動物體內時，可以產生短暫性的低血壓和心跳變慢；此作用與給藥劑量有直接的關連。在離體心房和心室的實驗，Matrine由50μg至200μg/ml的劑量下，可以增加心房自發性收縮和心室電刺激導致的收縮；但是，心房自發性跳動頻率會減少。Matrine對於離體標木，若連續給藥時並不產生耐藥性（Tachyphylaxis）。Matrine對於心房和心室產生的收縮增加，及心房跳動變慢作用，不被Diphenhydramine，Atropine，Phenoxybenza-mine，Propranolol，Trifluoperazine或Methysergide所阻斷。但是，Matrine對於心室產生的收縮增強作用，則因Ve-rapamil的存在而作用減弱。對於離體大動脈平滑肌標本，Matrine在200μg/ml的劑量可以稍微增加肌肉的張力；而同劑量的Matrine則可以增加35％的後腿灌注壓力。本實驗結果顯示Matrine對於動物所產生的短暫性血壓下降作用，可能與此藥所產生的心跳頻率減少比較有關；因為增強心房及心室收縮和某些血管收縮作用，不會是使血壓下降的原因。多種阻斷劑不能有效的對抗Matrine對於心臟血管系統的作用，此結果顯示Matrine所產生的上述作用，可能並不須通過這些受體而產生的。因此，本藥很可能是經由直接作用於細胞膜，而導致於一些離子（例如：鈣、鈉、鉀、氯等）通透度的改變；或者是對於細胞內鈣離子分佈的改變而來的。
• 英文摘要： Matrine, a pure compound isolated from the Chinese herb Shan-don-Gen (Sophora subprostrata),was studied for its effects on the cardiovascular system of the rat. Intravenous injections of matrine atdoses from 5 mg to 20 mg/kg body weight exhibited dose-dependent hypotensive and bradycardiac effects.These effects lasted only 1 to 3 min. In the isolated atria and ventricle preparations, matrine at doses from50 μg to 200 μg/ml increased the amplitudes of spontaneous contraction of the atria and electrically in-duced contraction of the ventricle, whereas the frequency of the spontaneous beating of the atria wasreduced. The dose-dependent effects of matrine on the isolated preparations persisted as long as the com-pound was present. Tachyphylaxis was not observed with repeated applications of this compound to theisolated preparations. The positive inotropic effects on both atria and ventricle and the negative chrono-tropic effect on spontaneous beating of the atria by matrine were not blocked by diphenhydramine, atro-pine, phenoxybenzamine, propranolol, trifluoperazine, or methysergide. In contrast, verapamil significantlyreduced the positive inotropic effect of matrine on the ventricle. In the isolated aortic strip preparation,matrine at a dose of 200 μg/ml led to a slight increase in muscle tone: The same dose of matrine induceda 35% increase of perfusion pressure in the hindleg perfusion model. These results suggest that the in vivotransient hypotensive effect of matrine is likely associated with a decrease in heart rate itself, since positiveinotropic effects on both the atria and the ventricle, and vasoconstriction of some vascular beds could notbe the cause of hypotension. The failure of various blocking agents to alter the cardiovascular effects ofmatrine suggests that these effects are not mediated through those receptors. Direct action on conductanceof ions (i.e. Ca++, Na+, K+, Cl- etc.) or the intracellular Ca++ provide alternative explanations.
• 中文關鍵字： Shan-dou-gen; matrine; cardiovascular system; hypotension; bradycardia; positive ino- tropic effect.
• 英文關鍵字： --