• 作者： 陳鏡如; 姜壽德
• 作者服務機構： 國立陽明醫學院生理學研究所
• 中文摘要： 雖然目前已經知道：大白鼠臨生產時子宮壁內同一層的平滑肌細胞之間會有gap junctions出現，因而造成肌肉層內同步而強烈的收縮。但是二個肌肉層之間的相互作用則少有探討。為了瞭解大白鼠懷孕末期二個子宮肌肉層間的關係，我們發展出一種可同時觀測一個標本內的二個肌肉層的技術。此種方法使用長方型的子宮壁條，以玻璃微電極測一個肌肉層的膜電位，並透過等長壓力轉換器記錄另一個肌肉層的收縮。 結果顯示，在某些標本，從孕期的第15、16天起子宮二肌肉層的收縮行為就有相互影響的現象。但是二個肌肉層間收縮行為的互相協調則必須等到孕期的第21天，並持續到生產之時。所謂協調性的收縮乃指縱肌的收縮與橫肌收縮有一特定的次序與時間間隔，此種關係反覆出現為時至少一小時。有時候協調性的收縮會呈一層的一個收縮配合另一層的二個收縮，此種配合並持續出現。我們認為這種肌肉層收縮的協調作用有助於生產之時將胎鼠推向子宮頸的動作。
• 英文摘要： Although it has been reported that, in the uterine wall of rats at term, gap junctions between fibersof the same muscle layer are responsible for synchronized strong contractions, much less attention has beenpaid to the interaction between muscle layers. To learn about the relationship between the two uterinemuscles of rats in late pregnancy, we developed a technique to do simultaneous monitoring of activitiesin two muscle layers. Using rectangular muscle strips, the electrical activity in one layer was measured withan intracellular microelectrode while the mechanical activity of the other layer was recorded through aforce transducer. In some of the uterine wall strips prepared from animals on gestation day 15 and 16, interactionbetween longitudinal and circular muscle layers was observed. However, well coordinated activities of thesetwo muscles did not occur until the morning of gestation day 21 and continued toward delivery. Usually,coordination presented as paired contractions, one in the circular muscle and the other in the longitud-inal muscle. While these pairs of contractions appeared regularly, they also kept similar intervals. Some-times, coordination presented as a continuous appearance of groups of three contractions, one in one layerand two in the other. Coordinating contractions of uterine muscles is considered to be beneficiary to thepropelling of fetuses toward the cervix during parturition.
• 中文關鍵字： uterus; smooth muscle; pregnancy; parturition; interaction between muscle layers
• 英文關鍵字： --